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Science. 2000 Aug 25;289(5483):1311-2.

Immunology. Therapeutic manipulation of gut flora.

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  • 1Department of Medicine, Cork University Hospital, Cork, Ireland. fshanahan@ucc.ie

Abstract

In developed countries as many as two individuals in every thousand suffer from inflammatory bowel disease (ulcerative colitis and Crohn's disease). In his Perspective, Shanahan discusses a new therapeutic approach to treating these conditions in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders (Steidler et al.).

PMID:
10979858
[PubMed - indexed for MEDLINE]
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