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Schizophr Res. 2000 Sep 29;45(1-2):1-9.

Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis.

Author information

  • 1Psychiatric Hospital of Rogaland, Armauer Hansensv. 20, Stavanger, Norway. tklarsen@online.no

Abstract

OBJECTIVE:

This study examines 1year outcome in patients having first-episode non-affective psychosis, with emphasis on Duration of Untreated Psychosis (DUP) and premorbid functioning, in order to clarify how these factors interact.

METHOD:

Forty-three consecutively admitted patients were all rated on the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning Scale (GAF), both upon hospitalization and at 1year follow-up. In addition, premorbid functioning, DUP, duration of hospitalization, and social functioning were rated.

RESULTS:

Fifty-six per cent were in remission, 18% suffered multiple relapses and 26% were continuously psychotic at 1 year follow-up. Both poor premorbid functioning and long DUP are significantly correlated with more negative symptoms and poorer global functioning at follow-up. Long DUP is also significantly correlated with more positive symptoms. Even when we control for other factors, including premorbid functioning and gender, DUP is a strong predictor of outcome. To a limited degree premorbid functioning and DUP interact, but DUP has an independent influence on outcome.

CONCLUSIONS:

these findings strengthen the rationale for establishing health service programs for early detection and treatment of first-onset psychosis

PMID:
10978867
[PubMed - indexed for MEDLINE]
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