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    Med J Aust. 1975 Jun 21;1(25):773-6.

    A controlled study of a tetracyclic antidepressant--maprotiline (Ludiomil).

    Abstract

    Maprotiline (Ludiomil) is a dibenzo bicyclooctadiene pharmacologically related to the tricyclic antidepressants and stereochemically having a tetracyclic structure. A controlled, double-blind comparison of maprotiline and imipramine in a group of 71 female outpatients with primary depression is presented. Maprotiline was found to be at least as effective as imipramine and significantly better in depressive neurosis. It also showed a bipolar action, being effective in both agitation and retardation.

    PMID:
    1097869
    [PubMed - indexed for MEDLINE]

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