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    Biochim Biophys Acta. 2000 Sep 7;1493(1-2):215-8.

    Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family.

    Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I.

    Source

    Division of Nephrology, UCLA School of Medicine, 10833 Le Conte Avenue, Room 7-155 Factor Building, 90095-1689, Los Angeles, CA, USA.

    Abstract

    We report the cloning, characterization and chromosomal assignment of a new member of the sodium bicarbonate cotransporter (NBC) family, NBC4, from human heart. NBC4 maps to chromosome 2p13 and is a new candidate gene for Alstrom syndrome. NBC4 encodes a 1074-residue polypeptide with 12 putative membrane-spanning domains. Unlike other members of the NBC family, NBC4 has a unique glycine-rich region (amino acids 438-485). In addition, NBC4 lacks the lysine-rich C-terminus of NBC1 with which it is most homologous. The first of two putative stilbene binding motifs (K(M/L)(X)K) is lacking in NBC4 (amino acids 655-658). The approximately 6 kb NBC4 transcript is moderately expressed in heart, with the highest expression in liver, testes and spleen.

    PMID:
    10978526
    [PubMed - indexed for MEDLINE]

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