Ann Neurol. 2000 Sep;48(3):297-303.

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.

Gibson GE, Haroutunian V, Zhang H, Park LC, Shi Q, Lesser M, Mohs RC, Sheu RK, Blass JP.

Source

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, White Plains, NY 10605, USA.

Abstract

Brain metabolism and the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a mitochondrial enzyme, are diminished in brains from patients with Alzheimer's disease (AD). In 109 subjects, the Clinical Dementia Rating (CDR) score was highly correlated with brain KGDHC activity. In AD patients who carried the epsilon 4 allele of the apolipoprotein E gene (ApoE4), the CDR score correlated better with KGDHC activity than with the densities of neuritic plaques or neuritic tangles. In contrast, in patients without ApoE4, the CDR score correlated significantly better with tangles and plaques than with KGDHC activity. The results suggest that mitochondrial/oxidative damage may be more important for the cognitive dysfunction in AD patients who carry ApoE4 than in those who do not.

PMID:: 10976635; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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Apolipoproteins E

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Alzheimer's Disease - MedlinePlus Health Information

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