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Ann Intern Med. 2000 Sep 19;133(6):401-10.

Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy.

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  • 1INSERM SC4, Faculté de Médecine St. Antoine, 27 rue Chaligny, 75571 Paris Cedex 12, France.

Abstract

BACKGROUND:

The prognostic value of discordant immunologic (CD4 cell increase) and virologic (plasma HIV RNA level decrease) responses to antiretroviral treatment is not known.

OBJECTIVE:

To study the relation between clinical outcome of HIV-infected patients receiving highly active antiretroviral therapy (HAART) and early immunologic and virologic responses to such therapy.

DESIGN:

Prospective cohort study.

SETTING:

68 hospitals in France.

PATIENTS:

2236 protease inhibitor-naive patients.

INTERVENTION:

Initiation of HAART with one protease inhibitor and two nucleoside analogues between July 1996 and March 1997.

MEASUREMENTS:

Immunologic and virologic response at 6 months. Multivariate Cox models were used to assess the relation between these responses and progression to a new AIDS-defining event or death.

RESULTS:

On the basis of 6-month immunologic and virologic responses, patients were classified into four groups: complete response (47.5%), complete nonresponse (16.2%), immunologic response only (19.0%), and virologic response only (17.3%). After month 6 and within a median of 18 months, 69 patients died and 123 experienced a new AIDS-defining event. After adjustment, complete nonresponders and those with only a virologic response had significantly higher risks for clinical progression at 6 months (relative risk, 3.38 [95% CI, 2.28 to 5.02] and 1.98 [CI, 1.26 to 3.10], respectively) than complete responders. The difference between complete responders and those with only an immunologic response at 6 months was weaker and nonsignificant (relative risk, 1.55 [CI, 0.96 to 2.50]).

CONCLUSIONS:

Immunologic response after 6 months of HAART indicates a favorable clinical outcome in HIV-infected patients regardless of virologic response. This suggests that both immunologic and virologic markers should be used in clinical practice to evaluate treatment response.

Comment in

PMID:
10975957
[PubMed - indexed for MEDLINE]
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