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Fertil Steril. 2000 Sep;74(3):482-6.

Blastocyst culture and transfer increases the efficiency of oocyte donation.

Author information

  • 1Colorado Center for Reproductive Medicine, Englewood, Colorado 80110, USA. bschoolcraft@colocrm.com

Abstract

OBJECTIVE:

To determine the impact of blastocyst transfer on an oocyte donation program.

DESIGN:

Retrospective review of embryo transfer in an IVF clinic.

SETTING:

Private assisted reproductive technology unit.

PATIENT(S):

Two hundred and twenty nine patients undergoing oocyte donation.

INTERVENTION(S):

Culture of pronucleate embryos to either day 3 or day 5 followed by embryo transfer.

MAIN OUTCOME MEASURE(S):

Implantation rates, pregnancy rates, and multiple gestations were analyzed.

RESULT(S):

Implantation rates and pregnancy rates were significantly increased by moving to extended embryo culture and transfer on day 5. After day 3 transfers, implantation and pregnancy rates were 47.1% and 75%, respectively. In contrast, on day 5 these rates were increased to 65.8% and 87.6%. Concomitantly, there were significantly fewer embryos transferred on day 5 (2.1) compared to day 3 (3.2).

CONCLUSION(S):

Blastocyst transfer is a highly effective treatment for patients who receive donor oocytes, allowing excellent pregnancy rates while significantly reducing the incidence of high-order multiple gestations.

PMID:
10973642
[PubMed - indexed for MEDLINE]
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