Acute neurologic decompensation in an infant with cobalamin deficiency exposed to nitrous oxide

K Felmet; B Robins; D Tilford; S J Hayflick

doi:10.1067/mpd.2000.107387

Acute neurologic decompensation in an infant with cobalamin deficiency exposed to nitrous oxide

J Pediatr. 2000 Sep;137(3):427-8. doi: 10.1067/mpd.2000.107387.

Authors

K Felmet¹, B Robins, D Tilford, S J Hayflick

Affiliation

¹ Departments of Pediatrics, Oregon Health Sciences University, Portland 97201, USA.

PMID: 10969273
DOI: 10.1067/mpd.2000.107387

Abstract

After exposure to nitrous oxide, an infant with unrecognized cobalamin deficiency developed neurologic deterioration and pancytopenia. Hematologic recovery and partial resolution of his neurologic changes followed repletion of the vitamin. Nitrous oxide depletes bioavailable cobalamin and may be a dangerous anesthetic in patients with cobalamin deficiency.

Publication types

Case Reports

MeSH terms

Anemia, Megaloblastic / etiology
Anesthetics, Inhalation / adverse effects*
Athetosis / etiology*
Developmental Disabilities / etiology*
Fatigue / etiology
Fever / etiology
Humans
Infant
Male
Nitrous Oxide / adverse effects*
Pancytopenia / etiology
Vitamin B 12 Deficiency / complications*

Substances

Anesthetics, Inhalation
Nitrous Oxide