Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2000 Sep 1;289(5484):1564-6.

Generation of G-to-A and C-to-U changes in HIV-1 transcripts by RNA editing.

Author information

  • 1Laboratoire de Réplication et Expression des Génomes Eucaryotes et Rétroviraux, UMR 5097, CNRS-Université Victor Segalen-Bordeaux 2, France.


RNA editing involves posttranscriptional alterations of messenger RNA (mRNA) sequences modifying the information content encoded by the genetic message. Here, it is shown that, in chronically infected H9 cells, human immunodeficiency virus-type 1 (HIV-1) mRNAs undergo guanine-to-adenine (G-to-A) and cytosine-to-uracil (C-to-U) changes. G-to-A modification in the untranslated region of exon 1 was present only in spliced HIV-1 mRNAs. The creation of stop codons in HIV-1 mRNAs may function to control the translation of viral proteins, such as viral protein R, that are involved in the regulation of HIV-1 expression and the survival of chronically infected cells.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk