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Regul Pept. 2000 Jul 28;91(1-3):13-20.

Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase.

Author information

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, 37232, Nashville, TN 37232, USA. satoru.eguchi@vanderbilt.edu

Abstract

In cultured vascular smooth muscle cells, the angiotensin II (AngII) type-1 (AT(1)) receptor generates growth-promoting signals via the epidermal growth factor (EGF) receptor system. This 'transactivation' mechanism now appears to be utilized by a variety of G-protein-coupled receptors in many cells. The AngII-induced EGF receptor transactivation leads to activation of downstream signaling molecules including Ras, ERK, c-fos, Akt/protein kinase B, and p70 S6 kinase. We propose three possible mechanisms may be involved in the transactivation, (i) an upstream tyrosine kinase, (ii) reactive oxygen species, and (iii) a juxtacrine activation of the EGF receptor ligand. Whether the EGF receptor signal transduction induced by AngII plays an essential role in cardiovascular remodeling remains to be investigated.

PMID:
10967198
[PubMed - indexed for MEDLINE]

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