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Am J Psychiatry. 2000 Sep;157(9):1509-11.

Sex differences in response to lithium treatment.

Author information

  • 1Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA. aviguera@partners.org

Abstract

OBJECTIVE:

Although sex differences occur with some psychotropic drug treatments, they are not well defined for mood-stabilizing agents, including lithium. The authors' goal was to investigate whether there are differences between the sexes in response to lithium.

METHOD:

Studies identified in a literature search were analyzed for reports of sex differences in clinical response to lithium in major affective syndromes.

RESULTS:

Data from 17 studies published in 1967-1998, involving 1,548 adults treated with lithium for a mean of 38.6 months (SD=30.5), yielded similar weighted response rates to lithium in 1,043 women (65.6% [N=684]) and 505 men (61.0% [N=308]).

CONCLUSIONS:

The results indicate little difference between the sexes in clinical response to lithium treatment of bipolar and related affective disorders.

PMID:
10964872
[PubMed - indexed for MEDLINE]
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