Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Psychiatry. 2000 Sep;157(9):1506-8.

Brain kinetics of paroxetine and fluoxetine on the third day of placebo substitution: a fluorine MRS study.

Author information

  • 1McLean Hospital, Belmont, MA 02478, USA. mehenry@mclean.harvard.edu

Abstract

OBJECTIVE:

This study tested whether a relationship exists between concentration and response following discontinuation of selective serotonin reuptake inhibitors.

METHOD:

Eight patients with remitted major depression who were taking 20 mg/day of either fluoxetine or paroxetine underwent placebo substitution for 3 days. Serum drug and brain fluorine levels were obtained before and after placebo substitution.

RESULTS:

With placebo substitution, a mean of 88% (SD=13%) of brain fluorine signal from fluoxetine (plus fluorinated metabolites) remained, compared with a mean of 38% (SD=17%) of the brain fluorine signal from paroxetine (plus fluorinated metabolites). Among patients taking paroxetine, adverse events during placebo substitution correlated highly with steady-state brain drug levels.

CONCLUSIONS:

The correlation of clinical effects with brain drug levels in the paroxetine group suggests that relationships between drug response and brain drug concentrations merit further investigation.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Write to the Help Desk