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Epilepsia. 2000 Aug;41(8):1046-8.

Effects of vagus nerve stimulation on progressive myoclonus epilepsy of Unverricht-Lundborg type.

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  • 1Department of Neurology, Henry Ford Health System, Detroit, Michigan, USA.

Abstract

PURPOSE:

A 34-year-old woman with progressive myoclonus epilepsy of Unverricht-Lundborg type was considered for vagus nerve stimulation (VNS) therapy.

METHODS:

After demonstration of intractability to multiple antiepileptic regimens and progressive deterioration in cerebellar function, the patient was implanted with a vagus nerve stimulator and followed for 1 year. Neurological status, seizure frequency, and parameter changes were analyzed.

RESULTS:

VNS therapy resulted in reduction of seizures (more than 90%) and a significant improvement in cerebellar function demonstrated on neurological examination. The patient reported improved quality of life based in part on her ability to perform activities of daily living.

CONCLUSIONS:

VNS therapy may be considered a treatment option for progressive myoclonus epilepsy. The effects of VNS on seizure control and cerebellar dysfunction may provide clues to the underlying mechanism(s) of action.

PMID:
10961635
[PubMed - indexed for MEDLINE]
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