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Mech Dev. 2000 Sep;96(2):259-62.

Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes.

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  • 1Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, Tucson, AZ, 85724, USA.

Abstract

The homeodomain transcription factor Nkx2-1 (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.

PMID:
10960795
[PubMed - indexed for MEDLINE]

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