Synthesis of enantiopure alpha,alpha-disubstituted amino acids from the asymmetric Strecker reaction products of aldehydes

Org Lett. 2000 Aug 10;2(16):2515-7. doi: 10.1021/ol0061891.

Abstract

Treatment of the enolates of 4 generated from the asymmetric Strecker reaction products with alkyl halides or aldehydes provided the corresponding functionalized products with high diastereoselectivity. Deprotection of these products afforded the corresponding enantiopure alpha,alpha-dialkyl amino acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes*
  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry
  • Indicators and Reagents
  • Models, Molecular
  • Molecular Conformation
  • Stereoisomerism

Substances

  • Aldehydes
  • Amino Acids
  • Indicators and Reagents