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J Rheumatol. 2000 Aug;27(8):1872-5.

Low dose weekly methotrexate in early pregnancy. A case series and review of the literature.

Author information

  • 1Center for Mothers with Rheumatic Disease, Department of Rheumatology, University Hospital of Trondheim, Norway. oestensen@aol.com

Abstract

OBJECTIVE:

To assess the teratogenic risk of low dose weekly pulses of methotrexate (MTX) inadvertently taken during the first trimester of pregnancy.

METHODS:

We assessed pregnancy and neonatal outcome of 4 patients with rheumatic disease treated with weekly pulses of 5 to 15 mg of MTX for a mean duration of 4 years.

RESULTS:

The 4 patients had continued MTX treatment from one to 6 weeks of gestation. One patient miscarried at Week 6, the other pregnancies ended with the delivery of healthy children. Chromosome analysis of one child was normal.

CONCLUSION:

In spite of the absence of congenital anomalies in our cases, safe contraception in fertile patients who start low dose weekly MTX is mandatory.

PMID:
10955326
[PubMed - indexed for MEDLINE]
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