J Immunol. 1979 May;122(5):2119-21.

A monoclonal IgG4 (lambda) with factor V inhibitory activity.

Hurtubise PE, Coots MC, Jacob DJ, Muhleman AF, Glueck HI.

Abstract

A monoclonal IgG4 (lambda) with inhibitory activity to human coagulation factor V was isolated from the serum of a patient with a fatal hemorrhagic diathesis by using a combination of DE-52 ion exchange chromatography and isoelectric focusing techniques. Using the criteria for defining a monoclonal immunoglobulin of restricted mobility on protein electrophoresis, immunoelectrophoresis, and isoelectric focusing, as well as neutralization with class, subclass, and light chain type antisera, we are the first to demonstrate a factor V inhibitor as a monoclonal IgG4 (lambda) detectable in serum or plasma.

PMID:: 109525; [PubMed - indexed for MEDLINE]

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[Determination of the subclasses of monoclonal human immunoglobulins G and of the light chain type with the aid of specific antisera]. [Zh Mikrobiol Epidemiol Immunob...]
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Cited by 6 PubMed Central articles

Inhibition of thromboxane A2 synthesis in human platelets by coagulation factor Xa. [Proc Natl Acad Sci U S A. 1983]
Inhibition of thromboxane A2 synthesis in human platelets by coagulation factor Xa.
Sinha AK, Rao AK, Willis J, Colman RW. Proc Natl Acad Sci U S A. 1983 Oct; 80(19):6086-90.
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Heterogeneity of human factor V deficiency. Evidence for the existence of antigen-positive variants.
Chiu HC, Whitaker E, Colman RW. J Clin Invest. 1983 Aug; 72(2):493-503.
Biosynthesis of factor V in isolated guinea pig megakaryocytes. [J Clin Invest. 1985]
Biosynthesis of factor V in isolated guinea pig megakaryocytes.
Chiu HC, Schick PK, Colman RW. J Clin Invest. 1985 Feb; 75(2):339-46.

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A monoclonal IgG4 (lambda) with factor V inhibitory activity.

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