Mayo Clin Proc. 2000 Aug;75(8):845-9.

Brugada-type electrocardiographic pattern induced by cocaine.

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Department of Internal Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.

Abstract

Right bundle branch block with coved ST-segment elevation in leads V1 through V3 is the electrocardiographic (ECG) marker of the Brugada syndrome. We describe a healthy young man with a normal baseline ECG in whom a transient Brugada pattern was observed repeatedly after recreational cocaine use. Intravenous administration of procainamide and subsequent intravenous propranolol followed by noradrenaline failed to reproduce the Brugada sign. An electrophysiologic study performed in the presence of the Brugada ECG pattern showed no inducible arrhythmias. This case illustrates that, in susceptible individuals, cocaine may provoke the Brugada sign. The clinical importance of this cocaine-induced ECG abnormality is currently unknown.

PMID:: 10943241; [PubMed - indexed for MEDLINE]

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Cited by 10 PubMed Central articles

Review Treatment of patients with cocaine-induced arrhythmias: bringing the bench to the bedside. [Br J Clin Pharmacol. 2010]
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Hoffman RS. Br J Clin Pharmacol. 2010 May; 69(5):448-57.
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O'Leary ME, Hancox JC. Br J Clin Pharmacol. 2010 May; 69(5):427-42.
Review Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org). [Heart Rhythm. 2009]
Review Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org).
Postema PG, Wolpert C, Amin AS, Probst V, Borggrefe M, Roden DM, Priori SG, Tan HL, Hiraoka M, Brugada J, et al. Heart Rhythm. 2009 Sep; 6(9):1335-41. Epub 2009 Jul 8.

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