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Arch Facial Plast Surg. 1999 Jul-Sep;1(3):165-70.

Autologous fibroblasts for treatment of facial rhytids and dermal depressions. A pilot study.

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  • 1Division of Head and Neck Surgery, University of California, Los Angeles, USA.

Abstract

OBJECTIVE:

To assess effectiveness of intradermal injections of autologous fibroblasts for the treatment of facial rhytids and dermal depressions.

DESIGN:

Six-month prospective pilot study. Photographs and silicone molds were taken of a prominent rhytid or dermal depression from each patient prior to treatment and at 6 months after treatment.

SETTING:

Specialty clinic in academic medical center.

PATIENTS:

Ten adults (age range, 24-69 years) who each exhibited a prominent rhytid or depressed facial scar.

INTERVENTION:

A 3-mm postauricular skin biopsy specimen from each participant was sent to Isolagen Technologies, Inc, laboratories, where a fibroblast cell line was developed. Three injection sessions were performed at 2-week intervals; target areas were the study site as well as behind the ear.

MAIN OUTCOME MEASURES:

Subjective improvement scores were obtained by each patient and 2 clinicians at every follow-up visit. Skin surface topographical features were evaluated with optical profilometry by comparing silicone molds before and after injection. Histological analysis was performed on a biopsy specimen of the postauricular injection site.

RESULTS:

Nine of 10 patients noted a 60% to 100% improvement with the treatment; clinicians made similar observations. Size reduction of 10% up to 85% of the study site was demonstrated by optical profilometry for every patient. Microscopically, there was evidence of increased thickness and density of dermal-layer collagen.

CONCLUSIONS:

Intradermal injection of autologous fibroblasts may be an effective treatment option for facial rhytids and depressed scars.

PMID:
10937098
[PubMed - indexed for MEDLINE]
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