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Semin Cancer Biol. 2000 Apr;10(2):83-92.

Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling.

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  • 1Department of Pharmacology, University of Illinois, Chicago 60612, USA.


Type I interferons are imperative in maintaining a defense against viral infection. These cytokines also play an important role in the control of cell proliferation. These effects are triggered by ligand binding to a specific cell surface receptor. In the present article, we attempt to analyze the advances made in the last four years on type I interferon signaling. This review will focus on the contribution of the cytoplasmic domain of the alpha and betaL chains of the receptor to the activation of the Jak-Stat pathway. We also analyze the possible role of other pathways in interferon signaling.

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