Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage

Fitoterapia. 2000 Aug:71 Suppl 1:S131-7. doi: 10.1016/s0367-326x(00)00188-x.

Abstract

This study examines the anti-ulcerogenic activity of eugenol, a natural compound obtained from many natural sources. Gastric ulcers, induced by administration of two ulcerogenic agents, i.e. platelet activating factor (PAF) and ethanol, were dose-dependently and significantly reduced by eugenol (10-100 mg/kg, p.o.) pre-treatment. Eugenol was able to reduce not only the number of ulcers but also the gravity of lesions.

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Ulcer Agents / administration & dosage
  • Anti-Ulcer Agents / pharmacology*
  • Anti-Ulcer Agents / therapeutic use
  • Dose-Response Relationship, Drug
  • Ethanol
  • Eugenol / administration & dosage
  • Eugenol / pharmacology*
  • Eugenol / therapeutic use
  • Gastric Mucosa / drug effects*
  • Male
  • Myristica*
  • Phytotherapy*
  • Platelet Activating Factor / toxicity
  • Rats
  • Rats, Wistar
  • Seeds
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / prevention & control*

Substances

  • Anti-Ulcer Agents
  • Platelet Activating Factor
  • Ethanol
  • Eugenol