Abstract
This study examines the anti-ulcerogenic activity of eugenol, a natural compound obtained from many natural sources. Gastric ulcers, induced by administration of two ulcerogenic agents, i.e. platelet activating factor (PAF) and ethanol, were dose-dependently and significantly reduced by eugenol (10-100 mg/kg, p.o.) pre-treatment. Eugenol was able to reduce not only the number of ulcers but also the gravity of lesions.
MeSH terms
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Administration, Oral
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Animals
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Anti-Ulcer Agents / administration & dosage
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Anti-Ulcer Agents / pharmacology*
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Anti-Ulcer Agents / therapeutic use
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Dose-Response Relationship, Drug
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Ethanol
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Eugenol / administration & dosage
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Eugenol / pharmacology*
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Eugenol / therapeutic use
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Gastric Mucosa / drug effects*
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Male
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Myristica*
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Phytotherapy*
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Platelet Activating Factor / toxicity
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Rats
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Rats, Wistar
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Seeds
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Stomach Ulcer / chemically induced
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Stomach Ulcer / prevention & control*
Substances
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Anti-Ulcer Agents
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Platelet Activating Factor
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Ethanol
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Eugenol