Eighty-one Taiwanese women (age range 31 to 79 years old) with palpable breast masses detected by mammography and or physical examination underwent technetium-99m methoxyisobutylisonitrile (Tc-99m-MIBI) scintimammography to assess its value in the detection of breast carcinomas and their differentiation from benign breast masses. The results showed that 58 of the 66 cases of breast carcinoma were detected by Tc-99m-MIBI scintimammography. Only 2 our of 15 patients with benign breast lesions had an abnormal scintimammographic finding. The mammography diagnosed 55 of the 66 cases of breast carcinoma, whilst 8 out of 15 patients with benign breast lesions had positive mammographic findings. The diagnostic sensitivity specificity and accuracy of Tc-99m-MIBI scintimammography were 88% 87% and 88%, respectively, whilst these parameters for mammography were 83%, 47% and 77%, respectively, regarding the differentiation of malignant from benign breast masses. We concluded that Tc-99m-MIBI scintimammography significantly improves the sensitivity and specificity for the detection of breast cancer in Taiwanese women with dense and small breasts.