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    Fitoterapia. 2000 Aug;71(4):450-2.

    Antibacterial activity of linoleic and oleic acids isolated from Helichrysum pedunculatum: a plant used during circumcision rites.

    Dilika F, Bremner PD, Meyer JJ.

    Source

    Department of Botany, University of Pretoria, Pretoria 0002, South Africa.

    Abstract

    The antibacterial activity-guided fractionation of the dichloromethane extract of leaves of Helichrysum pedunculatum resulted in the isolation of linoleic and oleic acids. Linoleic acid inhibited the growth of all the Gram-positive bacterial species tested with the minimum inhibitory concentration (MIC) varying between 0.01 and 1.0 mg/ml. Oleic acid was active against three of the five Gram-positive bacteria at a MIC of 1.0 mg/ml. Both compounds were inactive against the Gram-negative species tested. A synergistic effect between the two fatty acids was observed against Staphylococcus aureus and Micrococcus kristinae.

    PMID:
    10925024
    [PubMed - indexed for MEDLINE]

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