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Free Radic Biol Med. 2000 May 1;28(9):1328-37.

The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses.

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  • 1Immunobiology Program, Department of Medicine, University of Vermont, Burlington, VT 05405, USA.


The mitogen-activated protein (MAP) kinase family members, which include the extracellular response kinases (ERK), p38, and c-Jun amino terminal kinases (JNK), play a role in mediating signals triggered by cytokines, growth factors, and environmental stress. JNK and p38 MAP kinases have been involved in inflammatory processes induced by a variety of stimuli, such as oxidative stress. Here, we describe the role of the JNK and p38 MAP kinase signaling pathways in the development of T cells in the thymus, and activation and differentiation of T cells in the peripheral immune system.

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