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South Med J. 2000 Jul;93(7):650-5.

Actinic keratosis is squamous cell carcinoma.

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  • 1Division of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, USA.

Abstract

BACKGROUND:

The prevalence of nonmelanoma skin cancer in the United States is alarming. It can be most appropriately treated if the earliest manifestation of cutaneous squamous cell carcinoma is recognized.

METHODS:

Clinical, histologic, and molecular biology, considerations were reviewed to determine whether actinic keratosis is the earliest clinical manifestation of cutaneous squamous cell carcinoma.

RESULTS:

The clinical, histologic, and molecular parameters of actinic keratosis are those of squamous cell carcinoma.

CONCLUSION:

Actinic keratosis does not transform, convert, or progress into cutaneous squamous cell carcinoma but is the earliest clinically recognizable manifestation of this malignancy.

PMID:
10923948
[PubMed - indexed for MEDLINE]
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