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1: Biosci Biotechnol Biochem. 2000 Jun;64(6):1310-2. Links

New insecticidal bufadienolide, bryophyllin C, from Kalanchoe pinnata.

Supratman U, Fujita T, Akiyama K, Hayashi H.

Department of Applied Biological Chemistry, College of Agriculture, Osaka Prefecture University, Sakai, Japan.

Two insecticidal bufadienolides (1 and 2) were isolated from a methanol extract of the leaves of Kalanchoe pinnata by bioassay-guided fractionation. Compound 1 was identified as known bryophyllin A (bryotoxin C). The structure of new bufadienolide 2, named bryophyllin C, was determined by spectroscopic methods and the chemical transformation of 1. Compounds 1 and 2 showed strong insecticidal activity against third instar larvae of the silkworm (Bombyx mori), their LD50 values being evaluated as 3 and 5 microg/g of diet, respectively.

PMID: 10923811 [PubMed - indexed for MEDLINE]

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