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Arch Pathol Lab Med. 2000 Aug;124(8):1213-6.

Primary T-cell-rich B-cell lymphoma of the ethmoid sinus. A case report with 5 years of follow-up.

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  • 1Department of Pathology, Harbor-UCLA Medical Center, University of California Los Angeles, School of Medicine, and the Harbor-UCLA Research and Education Institute, USA.


T-cell-rich B-cell lymphoma (TCRBCL) is an uncommon and recently recognized variant of B-cell non-Hodgkin lymphoma characterized by a few large neoplastic B cells amid a predominant population of reactive T lymphocytes and variable numbers of histiocytes. Morphologically, TCRBCL resembles a variety of non-Hodgkin lymphomas and Hodgkin disease. Accurate diagnosis and proper treatment are essential to assure a favorable prognosis. To our knowledge, this is the first report of ethmoid sinus presentation of TCRBCL in an Epstein-Barr virus-negative 51-year-old man. Combined chemotherapy and radiotherapy were administered based on the correct diagnosis. The patient has had a complete response with no recurrence during the 5-year follow-up.

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