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Arch Pathol Lab Med. 2000 Aug;124(8):1165-7.

Prevalence and pathogenesis of pancreatic acinar tissue at the gastroesophageal junction in children and young adults.

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  • 1Department of Laboratories, North Shore University Hospital, New York University School of Medicine, Manhasset 11030, USA.

Abstract

BACKGROUND:

Pancreatic acinar tissue (PAT) at the gastroesophageal junction (GEJ) has been reported in 3% of adults with Barrett esophagus (BE) and in 24% of healthy subjects. The pathogenesis of this ectopic tissue is controversial. Both an acquired metaplastic process in the setting of BE and a congenital abnormality have been suggested in adults.

OBJECTIVE:

To clarify the origin of PAT at the GEJ.

METHODS:

We reviewed material obtained from the GEJ in 69 children and young adults. Each specimen was evaluated by 3 levels stained with hematoxylin-eosin for the presence of PAT, BE, esophagitis, and gastritis. Selected cases were also examined with immunohistochemical stains for lipase, trypsin, and amylase.

RESULTS:

In 16% of the study population, PAT was present at the GEJ and was not associated with BE. The prevalence of esophagitis and/or gastritis did not vary significantly between patients with and without PAT.

CONCLUSIONS:

Our data suggest that PAT at the GEJ develops independently of inflammation and is, therefore, likely to be congenital.

PMID:
10923077
[PubMed - indexed for MEDLINE]
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