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1: FEBS Lett. 2000 Jul 28;478(1-2):89-94.Click here to read Links

M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein.

Zhang F, Hogue DL, Liu L, Fisher CL, Hui D, Childs S, Ling V.

BC Cancer Research Centre, British Columbia Cancer Agency, University of British Columbia, 601 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada.

We have isolated a human cDNA encoding a novel ATP-binding cassette (ABC) protein whose gene was previously localized to chromosome 1q42 [Allikmets et al. (1995) Mamm. Genome 6, 111-117]. The gene transcript is expressed in all human tissues examined, with the highest levels in bone marrow. A non-expressed pseudogene also exists at chromosome 15q13-14. The new protein, which is most similar to the mitochondrial (M)-ABC1 protein, was also localized to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-ABC2 was shown to contain a mitochondrial-targeting signal sequence.

PMID: 10922475 [PubMed - indexed for MEDLINE]