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    Sheng Li Ke Xue Jin Zhan. 1997 Jan;28(1):29-34.

    [The discovery of pituitary adenylate cyclase activating polypeptide (PACAP) and its research progress]

    [Article in Chinese]

    Geng L, Ju G.

    Fourth Military Medical University, Institute of Neurosciences, Xi'an.

    Pituitary adenylate cyclase activating polypeptide(PACAP) is a new bioactive polypeptide originally isolated from ovine hypothalamus. It is widely distributed in the central and peripheral nervous systems, and some non-nervous tissues as well. Mediated by PACAP receptors, it stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. PACAP is not only a new type of hypophysiotropic hormone, but also functions as a neurotransmitter and neuromodulator. In addition, it plays a role in paracrine and autocrine regulation of certain types of cells.

    PMID: 10921074 [PubMed - indexed for MEDLINE]

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