[The discovery of pituitary adenylate cyclase activating polypeptide (PACAP) and its research progress]

Fourth Military Medical University, Institute of Neurosciences, Xi'an.

Pituitary adenylate cyclase activating polypeptide(PACAP) is a new bioactive polypeptide originally isolated from ovine hypothalamus. It is widely distributed in the central and peripheral nervous systems, and some non-nervous tissues as well. Mediated by PACAP receptors, it stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. PACAP is not only a new type of hypophysiotropic hormone, but also functions as a neurotransmitter and neuromodulator. In addition, it plays a role in paracrine and autocrine regulation of certain types of cells.

PMID: 10921074 [PubMed - indexed for MEDLINE]