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Zhonghua Zhong Liu Za Zhi. 1998 Sep;20(5):367-70.

[c-erbB2 gene amplification in human primary epithelial ovarian cancer and its clinical significance].

[Article in Chinese]

Author information

  • 1Shanghai Cancer Hospital, Shanghai Medical University.

Abstract

OBJECTIVE:

To study c-erbB2 gene amplification in human primary epithelial ovarian cancer and its clinical significance.

METHODS:

One hundred forty nine samples of primary epithelial ovarian tumors, including 34 beign tumors, 7 borderline tumors and 108 carcinoma, were studied for c-erbB2 gene amplification by Southern blot analysis.

RESULTS:

c-erbB2 gene amplification was detected in 35 (32.4%) of the 108 cases with primaey epithelial ovarian carcinoma, while all cases with beign tumors and borderline lesions were negative (P < 0.001). There was a strong correlation between c-erbB2 gene amplification and FIGO stage of human ovarian carcinoma (P = 0.026), degree of cell differentiation (P = 0.011) and the size of residual tumor (P < 0.001). Univariate and multivariate analysis showed that c-erbB2 gene amplification was an independent prognostic factor. The average 3-year survival rate was 28.4% in patients with gene amplification and 57.7% in patients without gene amplification(P = 0.016).

CONCLUSION:

c-erbB2 gene amplification occurs almost in 1/3 of the patients with ovarian carcinoma examined. Ovarian carcinoma with c-erbB2 gene amplification is highly malignant and associated with poor prognosis.

PMID:
10921034
[PubMed - indexed for MEDLINE]
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