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J Perinatol. 2000 Jul-Aug;20(5):335-7.

Candida chorioamnionitis after serial therapeutic amniocenteses: a possible association.

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  • 1Division of Maternal-Fetal Medicine, University of Pennsylvania Health System, Philadelphia 19104, USA. mrode@mail.obgyn.upenn.edu

Abstract

BACKGROUND:

Reduction amniocentesis is used in cases of severe polyhydramnios to decrease maternal discomfort and the risk of preterm labor. In a MEDLINE search (1966 to present, English language, keywords: amniocentesis, chorioamnionitis), no report of Candida chorioamnionitis after serial reduction amniocentesis exists.

CASE:

A 29-year-old primigravida with a history of four therapeutic amniocenteses for idiopathic polyhydramnios developed preterm labor at 30 and 5/7 weeks' gestation, rupture of membranes, and Candida albicans chorioamnionitis. Despite aggressive therapy with amphotericin B, the neonate succumbed to overwhelming systemic candidiasis.

CONCLUSION:

Serial amniocentesis may place patients at elevated risk for Candida chorioamnionitis and subsequent preterm delivery. Clinicians should consider early diagnostic amniocentesis in patients in preterm labor with a history of prior amniocentesis, and the routine Gram stain and culture of amniotic fluid.

PMID:
10920796
[PubMed - indexed for MEDLINE]
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