Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Bioessays. 2000 Aug;22(8):708-16.

Environmental signals and cell fate specification in premigratory neural crest.

Author information

  • 1Howard Hughes Medical Institute and Department of Pharmacology, University of Washington, Seattle, WA, USA. rdorsky@u.washington.edu

Abstract

Neural crest cells are multipotent progenitors, capable of producing diverse cell types upon differentiation. Recent studies have identified significant heterogeneity in both the fates produced and genes expressed by different premigratory crest cells. While these cells may be specified toward particular fates prior to migration, transplant studies show that some may still be capable of respecification at this time. Here we summarize evidence that extracellular signals in the local environment may act to specify premigratory crest and thus generate diversity in the population. Three main classes of signals-Wnts, BMP2/BMP4 and TGFbeta1,2,3-have been shown to directly influence the production of particular neural crest cell fates, and all are expressed near the premigratory crest. This system may therefore provide a good model for integration of multiple signaling pathways during embryonic cell fate specification.

Copyright 2000 John Wiley & Sons, Inc.

PMID:
10918301
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk