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Eur J Pharmacol. 2000 Jul 14;400(1):99-102.

Methamphetamine selectively alters brain glutathione.

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  • 1Program in Basic and Clinical Neuroscience, Department of Psychiatry, Case Western Reserve University, 44106, Cleveland, OH, USA.

Abstract

As methamphetamine-induced neurotoxicity has been proposed to involve oxidative stress, reduced and oxidized glutathione (GSH and GSSG, respectively), vitamin E and ascorbate were measured in the striata of rats killed 2 or 24 h after a neurotoxic regimen of methamphetamine. At 2 h, methamphetamine increased GSH and GSSG (32. 5% and 43.7%, respectively) compared to controls at 2 h. No difference was seen in glutathione at 24 h, and in vitamin E and ascorbate at either time point. These findings indicate selectivity of methamphetamine for the glutathione system and a role for methamphetamine in inducing oxidative stress.

PMID:
10913590
[PubMed - indexed for MEDLINE]
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