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Ann Oncol. 2000 May;11(5):527-33.

Long-term follow-up and residual sequelae after treatment for intracerebral germ-cell tumour in children and adolescents.

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  • 1University Children's Hospital, Zurich, Switzerland.

Abstract

BACKGROUND:

Information on long-term follow-up of children and adolescents treated for intracerebral germ-cell tumour is scant. We report on the results of a small series of patients treated at a single institution.

PATIENTS AND METHODS:

Hospital records from 15 patients treated between 1980 and 1998 were reviewed. An attempt was made to correlate sequelae to tumour location and treatment modalities.

RESULTS:

This cohort constitutes 5.5% of all brain tumours diagnosed at our institution.

HISTOLOGY:

10 germinomas, 2 benign teratomas, 2 malignant teratomas, and one mixed germ-cell tumour. Overall survival was 87%, with a mean follow-up time of 7 years and 8 months. The majority of patients have long-term sequelae involving one or several organ systems. In 66% endocrine, in 47% ophthalmologic, in 60% neuropsychological defects were observed. Endocrine and ophthalmologic sequelae show a correlation to tumour location. Neuropsychological long-term abnormalities are frequent and are associated with cranial irradiation in particular at young age, but less with tumour location, irradiation dose or surgery.

CONCLUSIONS:

Our preliminary data suggest that today intracerebral germinomas and mature teratomas have a good prognosis even when a relapse occurs. The outcome for mixed germ-cell tumours and malignant teratomas is less favourable. Although long-term sequelae are present in the majority of patients, there is some evidence that patients treated after 1990 suffer fewer severe long-term defects, thereby indicating that recent treatment protocols may result in a reduction of sequelae.

PMID:
10907944
[PubMed - indexed for MEDLINE]
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