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    J Appl Physiol. 2000 Jul;89(1):398-405.

    Effects of fiber composition and hindlimb unloading on the vasodilator properties of skeletal muscle arterioles.

    McCurdy MR, Colleran PN, Muller-Delp J, Delp MD.

    Collaborators (1)

    Delp MD.

    Source

    Department of Health and Kinesiology, Cardiovascular Research Institute, Texas A&M University, College Station, Texas 77843, USA.

    Abstract

    It has been hypothesized that microgravity-induced orthostatic hypotension may result from an exaggerated vasodilatory responsiveness of arteries. The purpose of this study was to determine whether skeletal muscle arterioles exhibit enhanced vasodilation in rats after 2 wk of hindlimb unloading (HU). First-order arterioles isolated from soleus and white gastrocnemius muscles were tested in vitro for vasodilatory responses to isoproterenol (Iso), adenosine (Ado), and sodium nitroprusside (SNP). HU had no effect on responses induced by Iso but diminished maximal vasodilation to Ado and SNP in both muscles. In addition, vasodilatory responses in arterioles from control rats varied between muscle types. Maximal dilations induced by Iso (soleus: 42 +/- 6%; white gastrocnemius: 60 +/- 7%) and Ado (soleus: 51 +/- 8%; white gastrocnemius: 81 +/- 6%) were greater in arterioles from white gastrocnemius muscles. These data do not support the hypothesis that microgravity-induced orthostatic hypotension results from an enhanced vasodilatory responsiveness of skeletal muscle arterioles. Furthermore, the data support the concept that dilatory responsiveness of arterioles varies in muscle composed of different fiber types.

    PMID:
    10904077
    [PubMed - indexed for MEDLINE]
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