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J Am Acad Dermatol. 2000 Aug;43(2 Pt 2):351-4.

Cutaneous malakoplakia: a report of two cases with the use of anti-BCG for the detection for micro-organisms.

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  • 1Pinkus Dermatopathology Laboratory, Monroe, MI 48161, USA.


Malakoplakia is an uncommon granulomatous infectious disease that is found primarily in the genito-urinary tract, but may rarely involve the skin. Histologic findings are marked by the presence of foamy macrophages containing basophilic concentric spherules, the Michaelis-Gutman bodies. Micro-organisms are not readily identifiable. Immunostaining with polyclonal anti-mycobacterium bovis (BCG) has been described as a method of identifying bacterial and fungal organisms in situations where organisms may be sparse. We report 2 cases of cutaneous malakoplakia with demonstration of organisms by immunostaining with anti-BCG antibodies.

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