Interactions between phenylephrine, clonidine and ...[Methods Find Exp Clin Pharmacol. 2000]

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1: Methods Find Exp Clin Pharmacol. 2000 Apr;22(3):145-7. Links

Interactions between phenylephrine, clonidine and xylazine in rat and rabbit aortas.

Atalik KE, Sahin AS, Doğan N.

Department of Pharmacology, Faculty of Medicine, University of Selçuk, Konya, Turkey.

The interaction of the alpha 2-adrenoceptor agonists clonidine and xylazine with the alpha 1-adrenoceptors in the rat and rabbit aortas was investigated. In preparations preconstricted with phenylephrine (10(-6) M), cumulative addition of clonidine and xylazine induced concentration-related vasodilatation in the presence of the alpha 2-adrenoceptor antagonist yohimbine and the beta-blocker propranolol. Neither clonidine nor xylazine treatment inhibited 5-HT- and KCl-induced vasoconstriction. It is concluded that alpha 2-agonists have affinity for alpha 1-adrenoceptors in rat and rabbit aortas.

PMID: 10893695 [PubMed - indexed for MEDLINE]

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