Am J Med Genet. 2000 Apr 3;96(2):235-9.

Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder.

DeLisi LE, Shaw S, Crow TJ, Shields G, Smith AB, Larach VW, Wellman N, Loftus J, Nathankumar B, Razi K, Kushner M, Stewart J, Vita A, Comazzi M, Sherrington R.

Source

Department of Psychiatry, SUNY Stony Brook, Stony Brook, New York 11794, USA. LdeLisi@notes.cc.sunysb.edu

Abstract

A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:235-239, 2000.

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