Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2000 Jun 9;101(6):647-56.

The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior.

Author information

  • 1Howard Hughes Medical Institute, National Science Foundation, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA.

Abstract

We report the characterization of a novel Drosophila circadian clock-regulated output gene, takeout (to). The to amino acid sequence shows similarity to two ligand binding proteins, including juvenile hormone binding protein. to mRNA is expressed in the head and the cardia, crop, and antennae-structures related to feeding. to expression is induced by starvation, which is blocked in all arrhythmic central clock mutants, suggesting a direct molecular link between the circadian clock and the feeding/starvation response. A to mutant has aberrant locomotor activity and dies rapidly in response to starvation, indicating a link between locomotor activity, survival, and food status. We propose that to participates in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activities.

PMID:
10892651
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk