Neurology. 2000 Jul 12;55(1):134-6.

Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype.

Moffat SD, Szekely CA, Zonderman AB, Kabani NJ, Resnick SM.

Source

Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Abstract

The epsilon4 allele of the apolipoprotein E (APOE) gene confers an increased risk for the development of AD. The authors compared longitudinal rates of change in hippocampal volume as a function of APOE genotype in nondemented elderly individuals. Rate of volumetric loss was significantly greater among epsilon4+ compared with epsilon4- individuals. These results indicate that individuals positive for the APOE epsilon4 allele may show a greater rate of hippocampal atrophy than their epsilon4- counterparts, even in the absence of a diagnosis of AD.

PMID:: 10891924; [PubMed - indexed for MEDLINE]

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Apolipoproteins E

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