J Pediatr. 2000 Jul;137(1):123-7.

Serum alpha-fetoprotein levels in Beckwith-Wiedemann syndrome.

Everman DB, Shuman C, Dzolganovski B, O'riordan MA, Weksberg R, Robin NH.

Source

Department of Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, OH 44106-6506, USA.

Abstract

We conducted a retrospective study that compared serial alpha-fetoprotein (AFP) concentrations obtained from 22 children with Beckwith-Wiedemann syndrome (BWS) with levels established for healthy children. The AFP concentration is greater in patients with BWS and declines during the postnatal period at a significantly slower rate than what is reported in healthy children. AFP levels obtained in the course of routine tumor screening in children with BWS should be interpreted with a normal curve established specifically for BWS rather than with previously published data for healthy infants and children.

PMID:: 10891834; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

alpha-Fetoproteins

Grant Support

T32 HD07518/HD/NICHD NIH HHS/United States

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