Identification and cloning of a gamma 3 subunit sp...[Brain Res Mol Brain Res. 2000]

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1: Brain Res Mol Brain Res. 2000 May 31;78(1-2):201-3. Links

Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor.

Poulsen CF, Christjansen KN, Hastrup S, Hartvig L.

Research Institute of Biological Psychiatry, St. Hans Hospital, DK-4000 Roskilde, Denmark. claus.fog.poulsen@shh.hosp.dk

cDNA sequences encoding two forms of the GABA(A) gamma 3 receptor subunit were cloned from human hippocampus. The nucleotide sequences differ by the absence (gamma 3S) or presence (gamma 3L) of 18 bp located in the presumed intracellular loop between transmembrane region (TM) III and IV. The extra 18 bp in the gamma 3L subunit generates a consensus site for phosphorylation by protein kinase C (PKC). Analysis of human genomic DNA encoding the gamma 3 subunit reveals that the 18 bp insert is contiguous with the upstream proximal exon.

PMID: 10891602 [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

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[Curr Neuropharmacol. 2008]

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Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor.

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