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Curr Opin Genet Dev. 2000 Aug;10(4):370-9.

Stepwise specification of lymphocyte developmental lineages.

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  • 1Division of Biology, California Institute of Technology, Pasadena 91125, USA. evroth@its.caltech.edu

Abstract

B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-lineage specification and commitment now illuminate this process.

PMID:
10889068
[PubMed - indexed for MEDLINE]
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