Diagn Cytopathol. 2000 Aug;23(2):134-9.

Intraoperative scrape cytology: comparison with frozen sections, using receiver operating characteristic (ROC) curve.

Shidham V, Gupta D, Galindo LM, Haber M, Grotkowski C, Edmonds P, Subichin SJ, George V, England J.

Source

Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. vshidham@mcw.edu

Abstract

The diagnostic role of intraoperative cytology (IC) has been demonstrated by many comparative studies. These studies have used sensitivity and specificity as statistical tools, based on binary principles. Statistical methods based on binary principles appear to be inappropriate for comparing anatomic pathology studies which involve significant human judgment with a range of subjective nonbinary result patterns. In this study, we applied the receiver operating characteristic (ROC) curve, which is based on probabilistic principles for the comparison of diagnostic accuracy with IC and frozen sections (FS). Seven observers studied a variable number of IC alone, FS alone, and IC/FS together from a pool of 446 specimens. The results were analyzed by ROC curve, using the MEDCALC software program (MedCalc Software, Mariakerke, Belgium). The accuracy with IC alone and FS alone was comparable. IC alone was diagnostic for many lesions, offering the choice of not freezing the tissue, and thus avoiding the introduction of artifacts. This strongly favors the routine practice of preparing IC during intraoperative consultation.

PMID:: 10888761; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Value of cytology as an adjunctive intraoperative diagnostic method. An audit of 2,250 consecutive cases. [Acta Cytol. 1997]
Value of cytology as an adjunctive intraoperative diagnostic method. An audit of 2,250 consecutive cases.
Scucchi LF, Di Stefano D, Cosentino L, Vecchione A. Acta Cytol. 1997 Sep-Oct; 41(5):1489-96.
Diagnostic accuracy of intraoperative imprint cytology in ovarian epithelial tumors. [Int J Gynaecol Obstet. 2001]
Diagnostic accuracy of intraoperative imprint cytology in ovarian epithelial tumors.
Nagai Y, Tanaka N, Horiuchi F, Ohki S, Seki K, Sekiya S. Int J Gynaecol Obstet. 2001 Feb; 72(2):159-64.
Intraoperative cytology increases the diagnostic accuracy of frozen sections for the confirmation of various tissues in the parathyroid region. [Am J Clin Pathol. 2002]
Intraoperative cytology increases the diagnostic accuracy of frozen sections for the confirmation of various tissues in the parathyroid region.
Shidham VB, Asma Z, Rao RN, Chavan A, Machhi J, Almagro U, Komorowski RA. Am J Clin Pathol. 2002 Dec; 118(6):895-902.
Review [Intraoperative cytology of breast lesions]. [Clin Exp Pathol. 1999]
Review [Intraoperative cytology of breast lesions].
Briffod M, Cabaret V, Trassard M, Labbé S. Clin Exp Pathol. 1999; 47(6):279-85.
Review Practical issues of intraoperative frozen section diagnosis of bone and soft tissue lesions. [Cancer Control. 2008]
Review Practical issues of intraoperative frozen section diagnosis of bone and soft tissue lesions.
Bui MM, Smith P, Agresta SV, Cheong D, Letson GD. Cancer Control. 2008 Jan; 15(1):7-12.

See reviews... See all...

Cited by 3 PubMed Central articles

Role of scrape cytology in the intraoperative diagnosis of tumor. [J Cytol. 2010]
Role of scrape cytology in the intraoperative diagnosis of tumor.
Kolte SS, Satarkar RN. J Cytol. 2010 Jul; 27(3):86-90.
Comparison of conventional, nested, and real-time quantitative PCR for diagnosis of scrub typhus. [J Clin Microbiol. 2011]
Comparison of conventional, nested, and real-time quantitative PCR for diagnosis of scrub typhus.
Kim DM, Park G, Kim HS, Lee JY, Neupane GP, Graves S, Stenos J. J Clin Microbiol. 2011 Feb; 49(2):607-12. Epub 2010 Nov 10.
Comparison of conventional, nested, and real-time PCR assays for rapid and accurate detection of Vibrio vulnificus. [J Clin Microbiol. 2008]
Comparison of conventional, nested, and real-time PCR assays for rapid and accurate detection of Vibrio vulnificus.
Kim HS, Kim DM, Neupane GP, Lee YM, Yang NW, Jang SJ, Jung SI, Park KH, Park HR, Lee CS, et al. J Clin Microbiol. 2008 Sep; 46(9):2992-8. Epub 2008 Jul 9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Intraoperative scrape cytology: comparison with frozen sections, using receiver ...
Intraoperative scrape cytology: comparison with frozen sections, using receiver operating characteristic (ROC) curve.
Diagn Cytopathol. 2000 Aug ;23(2):134-9.

PubMed
Hemoglobin Moabit: alpha 86 (F7) Leu leads to Arg: a new unstable abnormal hemog...
Hemoglobin Moabit: alpha 86 (F7) Leu leads to Arg: a new unstable abnormal hemoglobin.
Acta Haematol. 1979 ;61(3):121-4.

PubMed
An evaluation of an innovative multimedia educational software program for asthm...
An evaluation of an innovative multimedia educational software program for asthma management: report of a randomized, controlled trial.
Pediatrics. 2000 Jul ;106(1 Pt 2):210-5.

PubMed
The virus-specific and allospecific cytotoxic T-lymphocyte response to lymphocyt...
The virus-specific and allospecific cytotoxic T-lymphocyte response to lymphocytic choriomeningitis virus is modified in a subpopulation of CD8(+) T cells coexpressing the inhibitory major histocompatibility complex class I receptor Ly49G2.
J Virol. 2000 Aug ;74(15):7032-8.

PubMed
Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length...
Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients.
Hum Mol Genet. 2000 Jun 12 ;9(10):1501-13.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Intraoperative scrape cytology: comparison with frozen sections, using receiver operating characteristic (ROC) curve.

Source

Abstract

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information