Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 2000 Aug;10(8):335-42.

Ubiquitin and its kin: how close are the family ties?

Author information

  • 1Dept of Molecular Cell Biology, Max Planck Institute for Biochemistry, Martinsried, Germany.

Abstract

Modification of proteins by the covalent attachment of ubiquitin is known to target them for degradation by proteasomes. Several proteins have been discovered recently that are related to ubiquitin or function similarly. Some of these proteins act as modifiers; others bear ubiquitin-like domains embedded in their polypeptide chain but do not form conjugates with cellular proteins. Ubiquitin-like proteins mediate an impressive range of cellular functions, including cell-cycle progression, DNA repair and apoptosis. Recent discoveries endorse the view that, in many cases, the function of the relatives of ubiquitin is linked to the ubiquitin pathway.

PMID:
10884686
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk