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J Infect Dis. 2000 Jul;182(1):351-5. Epub 2000 Jul 6.

Screening for Staphylococcus epidermidis markers discriminating between skin-flora strains and those responsible for infections of joint prostheses.

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  • 1Unité des Staphylocoques, Centre National de Référence des Staphylocoques, Institut Pasteur, Paris, and Service de Microbiologie, Hôpital Beaujon, A.P.-H.P., Clichy, France.


Fifty-four Staphylococcus epidermidis strains responsible for infections of joint prostheses and 23 strains isolated from skin flora were studied for markers of virulence, to discriminate invasive strains from normal flora. They were screened for binding to polystyrene and matrix proteins and for the presence of staphylococcal genes involved in adhesion. The ica operon involved in biofilm formation was the only marker discriminating between these 2 categories of strains.

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