Rev Hosp Clin Fac Med Sao Paulo. 2000 Jan-Feb;55(1):17-20.

Müllerian adenosarcoma of the uterus with sarcomatous overgrowth following tamoxifen treatment for breast cancer.

Carvalho FM, Carvalho JP, Motta EV, Souen J.

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Department of Gynecology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Brazil.

Abstract

Müllerian adenosarcoma with sarcomatous overgrowth presented by a 52-year-old female patient after adjuvant tamoxifen treatment for breast carcinoma is described. The diagnosis was made on histological basis after curettage and complementary total hysterectomy with bilateral salpingo-oophorectomy. The immunohistochemical study showed high expression of estrogen receptors in the epithelial component of the lesion and irregularly positive findings in the stroma. The proliferative activity evaluated by Ki-67 immunoexpression was higher in the stroma than the epithelium. Some of the stromal cells showed rhabdomyoblastic differentiation. The association of tamoxifen use and development of mesenchymal neoplasms is discussed.

PMID:: 10881074; [PubMed - indexed for MEDLINE]

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