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Cancer Lett. 2000 Aug 11;156(2):159-65.

Enhanced oncogenicity of human papillomavirus type 16 (HPV16) variants in Japanese population.

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  • 1Department of Obstetrics and Gynecology, University of Tokyo, 1-7-1, Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan.


To investigate whether HPV16 E6 variants carry an elevated risk for cervical cancer in Japanese population, we investigated the E6 sequence variation in 40 cervical intraepithelial neoplasias (CINs) I-III and 43 invasive cervical cancers (ICCs), all positive for HPV16. HPV16 E6 variants were frequently found in ICCs than in CINs (88 vs. 65%, P=0.01). The E6 D25E, a rare variant in Western countries, was most frequently observed in ICC (44%). CIN I/II lesions with HPV16 variants were less likely to regress than those with HPV16 prototype (P=0.048). The finding that HPV16 E6 variants represent a significant risk factor is common between Western and Japanese women despite the different distribution of each variant.

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