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Nihon Rinsho. 2000 Jun;58(6):1315-25.

[Genome analysis of pathogenic bacteria--a review].

[Article in Japanese]

Author information

  • Department of Microbiology, Yamaguchi University School of Medicine.


The whole genome information on pathogenic bacteria opened a new era of medical microbiology. Bacteria have a variety of strategies to survive in human body against host defense. Bacteria colonizing on the mucous cell surface and proliferate extracellularly have developed a number of paralogs of surface proteins for antigenic variation, while bacteria which proliferate intracellularly have acquired genes for invasion and anti-active oxygen. The obligate intracellular parasites, Rickettsiae and Chlamydiae, have developed a distinct energy metabolism depending on the intracellular localization; Rickettsia prowazekii has TCA cycle and oxidative phosphorylation to proliferate in the cytoplasm, while Chlamydiae have a glycolytic pathway and substrate-level phosphorylation to multiply within an organella called inclusion bodies.

[PubMed - indexed for MEDLINE]
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